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Evidence for inhibition of cholinesterases in insect and mammalian nervous systems by the insect repellent deet

Vincent Corbel13*, Maria Stankiewicz2, Cédric Pennetier14, Didier Fournier5, Jure Stojan6, Emmanuelle Girard7, Mitko Dimitrov5, Jordi Molgó7, Jean-Marc Hougard3 and Bruno Lapied4*

Author Affiliations

1 Laboratoire de Lutte contre les Insectes Nuisibles, Institut de Recherche pour le Développement, F-34 394 Montpellier, France

2 Institute of General & Molecular Biology, N. Copernicus University, 87-100 Torun, Poland

3 Institut de Recherche pour le Développement/Centre de Recherches Entomologiques de Cotonou, 01 BP 4414, République du Bénin

4 Laboratoire Récepteurs et Canaux Ioniques Membranaires (RCIM), UPRES EA 2647/USC INRA 2023, IFR 149 QUASAV, Université d'Angers, UFR Sciences, F-49045 Angers cedex, France

5 Groupe de Biotechnologie des protéines, Université de Toulouse, Toulouse, France

6 Institute of Biochemistry, Medical Faculty, University of Ljubljana, Slovenia

7 CNRS, Institut de Neurobiologie Alfred Fessard – FRC2118, Laboratoire de Neurobiologie Cellulaire et Moléculaire – UPR9040, Gif sur Yvette, F-91198, France

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BMC Biology 2009, 7:47  doi:10.1186/1741-7007-7-47

Published: 5 August 2009

Additional files

Additional file 1:

Reaction scheme for substrate hydrolysis by cholinesterases in the presence of a reversible inhibitor that competes at the peripheral anionic and the catalytic site of the free and acetylated enzyme.

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