Research article
Evidence for inhibition of cholinesterases in insect and mammalian nervous systems by the insect repellent deet
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* Corresponding authors: Vincent Corbel vincent.corbel@ird.fr - Bruno Lapied bruno.lapied@univ-angers.fr
1 Laboratoire de Lutte contre les Insectes Nuisibles, Institut de Recherche pour le Développement, F-34 394 Montpellier, France
2 Institute of General & Molecular Biology, N. Copernicus University, 87-100 Torun, Poland
3 Institut de Recherche pour le Développement/Centre de Recherches Entomologiques de Cotonou, 01 BP 4414, République du Bénin
4 Laboratoire Récepteurs et Canaux Ioniques Membranaires (RCIM), UPRES EA 2647/USC INRA 2023, IFR 149 QUASAV, Université d'Angers, UFR Sciences, F-49045 Angers cedex, France
5 Groupe de Biotechnologie des protéines, Université de Toulouse, Toulouse, France
6 Institute of Biochemistry, Medical Faculty, University of Ljubljana, Slovenia
7 CNRS, Institut de Neurobiologie Alfred Fessard – FRC2118, Laboratoire de Neurobiologie Cellulaire et Moléculaire – UPR9040, Gif sur Yvette, F-91198, France
BMC Biology 2009, 7:47 doi:10.1186/1741-7007-7-47
Published: 5 August 2009Additional files
Additional file 1:
Reaction scheme for substrate hydrolysis by cholinesterases in the presence of a reversible inhibitor that competes at the peripheral anionic and the catalytic site of the free and acetylated enzyme.
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