Figure 7.

A model of the regulation of TATA-box binding proteins during early stages of embryogenesis. Oocytes express TBP2 which is involved in initiation of transcription. Upon meiotic maturation, global repression of transcription is established and TBP2 is actively degraded. During early cleavages after fertilization, maternal stores of TBP mRNA are translated [15] and by the mid-blastula transition (MBT) both TBP and residual TBP2 contribute to zygotic transcription [8,9].