Table 2

General linear mixed model prediction of tumour necrosis factor alpha (pg/ml) responses in louse-free wood mice and wood mice in the heaviest louse infection category.

Response

Uninfected

Heavy infection

%Δ^‡

TLR2/heat-killed Listeria monocytogenes

560 (42)

284 (65)

-49.3%

TLR2/zymosan^†

418 (89)

187 (123)

-55.2%

TLR9

277 (22)

113 (35)

-59.2%

TIR

1463 (144)

647 (214)

-55.8%

Results for model: untransformed tumour necrosis factor alpha (TNF-α) (pg/ml) ~sex + snout-vent length + season + trap group; random model, trap day/process day/assay plate.

^†The TLR2/zymosan general linear mixed model for untransformed TNF-α was a relatively poor fit to the data, but results for this model, which are highly consistent with model predictions for the other variables, are presented to maintain direct comparability. TIR = total TNF-α (pg/ml) response summed over all receptor-ligand combinations. Standard errors are given in parentheses.

^‡Percentage change between the uninfected and heaviest infection categories.

Jackson et al. BMC Biology 2009 7:16   doi:10.1186/1741-7007-7-16