Table 1

Significant gene ontology terms for changed genes

upregulated

downregulated



NR5 and NR14 (N = 111)

NR5 and NR14 (N = 104)


extracellular region (N = 14; 9.05E-07)

muscle contraction (N = 13; 1.81E-10)

collagen catabolism (N = 5; 4.35E-06)

cytoplasm (N = 51; 8.41E-07)

collagen (N = 6; 4.05E-05)

ion transport (N = 12; 9.44E-06)


NR5 only (N = 110)

NR5 only (N = 49)


extracellular region (N = 15; 1.23E-05)

extrinsic to membrane (N = 3; 6.10E-03)

response to stimulus (N = 17; 1.00E-02)

signal transduction (N = 21; 2.89E-03)

Ion transport (N = 9; 2.57E-03)


NR14 only (N = 53)

NR14 only (N = 93)


DNA metabolic process (N = 8; 4.41E-04)

muscle contraction (N = 18; 5.43E-19)

calcium ion binding (N = 11; 4.98E-04)


DL5 and DL14 (N = 170)

DL5 and DL14 (N = 109)


extracellular region (N = 23; 6.64E-10)

muscle contraction (N = 15; 6.62E-13)

lysosome (N = 11; 3.04E-08)

cytoplasm (N = 53; 1.46E-06)

ion transport (N = 13; 1.42E-05)

mitochondrial membrane (N = 12; 3.49E-04)

hydrolase activity (N = 26; 3.60E-05)

response to stress (N = 21; 1.02E-03)

signal transduction (N = 22; 5.40E-03)

collagen catabolism (N = 5; 5.09E-05)


DL5 only (N = 68)

DL5 only (N = 58)


extracellular region (N = 9; 3.68E-04)

extrinsic to membrane (N = 3; 4.64E-03)

response to stimulus (N = 12; 3.70E-03)


DL14 only (N = 69)

DL14 only (N = 111)


extracellular region (N = 7; 4.10E-03)

muscle contraction (N = 9; 4.26E-05)

immune response (N = 5; 7.80E-03)

mitochondrion (N = 27; 6.71E-07)

cytoplasmic (N = 43; 2.58E-03)

M phase (N = 9; 1.40E-03)

glucose metabolic process (N = 6; 2.97E-03)


Significant genes were identified by microarray analysis. Gene ontology terms are represented that were sampled more often than expected in NR5, NR14, DL5, and DL14 limbs. P-value is calculated by DAVID [45].

Monaghan et al. BMC Biology 2009 7:1   doi:10.1186/1741-7007-7-1

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