Table 3 |
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|
Correlation between PrPSc and activated cPLA2 in ScGT1 cells. The amounts of PrPSc and activated cPLA2 (phosphorylated at serine 505) in ScGT1 and GT1 cells treated for 7 days with neurotrophic factors or retinoic acid as shown. Values shown are the mean ± SD from 9 samples. PrPSc content of cells significantly greater than those of untreated cells (P < 0.05) are indicated by * and amounts of activated cPLA2 significantly greater than those of untreated cells (P < 0.05) are indicated by #. |
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|
PrPSc (ng/ml) |
Activated cPLA2 (units) |
|||
|
|
||||
|
ScGT1 |
GT1 |
ScGT1 |
GT1 |
|
|
|
||||
|
Control |
6.9 ± 0.2 |
- |
395 ± 33 |
100 ± 18 |
|
10 ng/ml BDNF |
15.2 ± 1.4* |
- |
514 ± 69# |
102 ± 7 |
|
10 ng/ml GDNF |
14.2 ± 0.5* |
- |
542 ± 65# |
109 ± 9 |
|
10 ng/ml NGF |
7.4 ± 1.7 |
- |
416 ± 46 |
98 ± 6 |
|
100 nM retinoic acid |
16.5 ± 2.1* |
- |
553 ± 79# |
113 ± 13 |
|
|
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|
Bate et al. BMC Biology 2008 6:8 doi:10.1186/1741-7007-6-8 |
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