Expression of Wnt7b, Wnt9b, and Wnt11 in E18.5 Pygo1/Pygo2 compound null kidneys. Whole-mount in situ of hybridizations of (A-C) E18.5 wild-type kidneys and (D-F) Pygo1-/-/Pygo2-/- mutant kidneys with the ureteric bud derivative markers: (A, D) Wnt7b, (B, E) Wnt9b, and (C, F) Wnt11. The mutant kidneys showed normal expression patterns for the ureteric stalk markers Wnt7b and Wnt9b, and reduced density of ureteric tips as measured by Wnt11. Original magnification × 32.
Schwab et al. BMC Biology 2007 5:15 doi:10.1186/1741-7007-5-15