Sequence variation in human succinate dehydrogenase genes: evidence for long-term balancing selection on SDHA

doi:10.1186/1741-7007-5-12

BMC Biology

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Occupational inhibitors of SDH

Heikki Savolainen (21 May 2007) Dept. of Occup. Safety & Hlth., Tampere, Finland

The authors show that mutations of SDH A are not primarily associated with the tumorigenesis while impairment of its activity leads to serious failures in energy metabolism. They also refer to xenobiotic inhibitors of the SDH complex.

It has been shown that alkoxyacetic acid metabolites from occupational exposure to ethylene glycol ethers, common solvents in water miscible paints, are SDH inhibitors (1, 2) which could explain e.g. oligospermia in ship painters (3) or postulated carcinogenic effects.

1 Laitinen J, Liesivuori J, Turunen H, Savolainen H. 1994. Urinary biochemistry in occupational exposure to glycol ethers. Chemosphere 29: 781-787

2 Liesivuori J, laitinen J, Savolainen H. 1999. Rat model for renal effects of 2-alkoxyalcohols and their acetates. Arch Toxicol 73: 229-232

3 Welch LS, Schrader SM, Turner TW, Cullen MR. 1988. Effects of exposure to ethylene glycol ethers on shipyard painters: II. Male reproduction. Am J Ind Med 14: 509-528

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Sequence variation in human succinate dehydrogenase genes: evidence for long-term balancing selection on SDHA

Occupational inhibitors of SDH

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