Figure 7.

Model of how starvation and AGE-1 regulate somatic-maintenance gene expression by regulating DAF-16 localisation. Firstly, DAF-16 translocates to the nucleus in response to starvation. In the nucleus DAF-16 activates the transcription of somatic-maintenance genes until an unknown feedback mechanism causes the activation of AGE-1, which results in DAF-16 translocating back to the cytoplasm. This feedback is absent in age-1(hx546) mutants causing increased stress resistance in starved animals or ageing adults.