Figure 3.

Mitochondrial dysfunction induces stress responses or mitophagy. Loss of mitochondrial electron transport chain function and/or misfolded proteins in mitochondrial matrix induces expression of genes through decreases in mitochondrial membrane potential. Sustained loss of mitochondrial membrane potential can invoke mitophagy, a process to eliminate dysfunctional mitochondria.

Chandel BMC Biology 2014 12:34   doi:10.1186/1741-7007-12-34
Download authors' original image