Interactions between neurites and migrating ENCCs at the migratory wavefront. A. A diagram showing photoconversion of all ENCCs, except the most caudal ENCCs, which results in photoconversion of the caudally-projecting neurites. B. The tip (open arrow) of a red, caudally-projecting neurite (arrows) is located at the back of the most caudal cell (yellow asterisk). C. The tip (open arrow) of a red neurite (arrows) advances slightly behind a migrating ENCC. Even though the neurite advanced in association with migrating ENCCs, 2.5 hours later, there were few ENCCs associated with some sections of the neurite (arrows). D. The tip (open arrow) of a caudally projecting neurite (arrows) is just rostral to the most caudal group of ENCCs, but it acts as a substrate for ENCCs (blue, pink and white asterisks) just behind the most caudal ENCCs. E. Adhesive interactions between a neurite (red) and a migrating ENCC. F. Not all chains of ENCCs have neurites associated with them. Two ENCCs (white and blue asterisks) extend caudally as a chain. After they lose contact with the ENCCs behind and join another chain, no neurites are visible (boxed area). ENCCs, enteric neural crest-derived cells.
Young et al. BMC Biology 2014 12:23 doi:10.1186/1741-7007-12-23