Open Access Research article

Plasmodium falciparum encodes a conserved active inhibitor-2 for Protein Phosphatase type 1: perspectives for novel anti-plasmodial therapy

Aline Fréville1, Katia Cailliau-Maggio2, Christine Pierrot1, Géraldine Tellier1, Hadidjatou Kalamou1, Sophia Lafitte1, Alain Martoriati2, Raymond J Pierce1, Jean-François Bodart2 and Jamal Khalife1*

Author Affiliations

1 Center for Infection and Immunity of Lille, Inserm U1019-CNRS UMR 8204, University of Lille Nord de France, Institut Pasteur de Lille, 1 Rue du Professeur Calmette, 59019 Lille, Cedex, France

2 EA4479, IFR147, Laboratoire de Régulation des Signaux de Division, SN3, Université des Sciences et Technologies de Lille, 59655 Villeneuve d’Ascq, France

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BMC Biology 2013, 11:80  doi:10.1186/1741-7007-11-80

Published: 9 July 2013

Additional files

Additional file 1: Table S1:

List of the primers used throughout this study.

Format: TIFF Size: 582KB Download file

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Additional file 2: Figure S1:

Nucleotide sequence of P. falciparum inhibitor 2. Sequence of PfI2 obtained by RT-PCR using different sets of primers to confirm the start and the stop codons. The 5 and 3 non -coding sequences are presented in italic. The start and stop codons are bolded.

Format: TIFF Size: 1.1MB Download file

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Additional file 3: Table S2:

list of the peptides used throughout this study.

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Additional file 4: Table S3:

list of the proteins present in genomic database used in the phylogenetic analysis.

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Additional file 5: Figure S2:

Optimized sequence of PfI2 used throughout this study for recombinant protein expression and interaction studies in yeast.

Format: TIFF Size: 819KB Download file

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