Figure 1.

Schematic map of MCPH1 protein domains labeled with lineage-specific amino acid substitutions. Sites containing human specific substitutions are marked with shadows, and the two dramatic brain size enlargement events that coincided with the molecular signatures of Darwinian positive selection during primate evolution are indicated.

Shi et al. BMC Biology 2013 11:62   doi:10.1186/1741-7007-11-62
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