Additional file 2.

Conversion of 5mC to 5caC in synthetic oligonucleotides. Kinetic signals for synthetic oligonucleotides carrying two 5mC modified sites (red bars) are shown before (top) and after (bottom) mTet1-mediated oxidation to 5caC. IPD ratio data are plotted for each template position relative to a control template of identical sequence but lacking modifications. The template is shown in the 5' to 3' direction from left to right, the polymerase movement is right to left across the template as indicated by the arrow.

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Clark et al. BMC Biology 2013 11:4   doi:10.1186/1741-7007-11-4