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Open Access Highly Accessed Research article

Copy-number variation of cancer-gene orthologs is sufficient to induce cancer-like symptoms in Saccharomyces cerevisiae

Michaela de Clare and Stephen G Oliver*

Author Affiliations

Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK

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BMC Biology 2013, 11:24  doi:10.1186/1741-7007-11-24

Published: 25 March 2013

Additional files

Additional file 1: Table S1:

List of S.cerevisiae haploproficient genes.

Format: XLSX Size: 75KB Download file

Open Data

Additional file 2: Table S2:

Haploproficient members of the major complexes within the S.cerevisiae cell cycle.

Format: DOCX Size: 44KB Download file

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Additional file 3: Table S3:

Chronological lifespan data for heterozygous deletion mutants of the HPGI set compared with control strains.

Format: XLSX Size: 50KB Download file

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Additional file 4: Table S4:

Cell cycle profiling data for the heterozygous and homozygous deletion mutants of the HPGI set, and control strains.

Format: XLSX Size: 50KB Download file

Open Data

Additional file 5: Table S5:

Growth phenotypes of heterozygous deletion mutants of genes encoding subunits of the yeast PP2A complex.

Format: DOCX Size: 47KB Download file

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Additional file 6: Table S6:

Yeast strains used in this study.

Format: DOCX Size: 145KB Download file

Open Data