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Revisiting the relationship between regenerative ability and aging

Ashley W Seifert12 and S Randal Voss13*

Author affiliations

1 Department of Biology, University of Kentucky, Lexington, KY 40506, USA

2 Department of Biology, University of Florida, Gainesville, FL 32601, USA

3 Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40506, USA

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Citation and License

BMC Biology 2013, 11:2  doi:10.1186/1741-7007-11-2

Published: 21 January 2013


Contrary to the longstanding view that newts (Notophthalamus viridescens), but not axolotls (Ambystoma mexicanum), can regenerate a lens, a recent report in BMC Biology by Panagiotis Tsonis and colleagues shows axolotls indeed possess this ability during early larval stages. In contrast, they show that zebrafish never posses this ability, even as embryos. This underscores the importance of comparing regenerative ability across species and reinforces the need to consider organ regeneration in the context of evolution, development, and aging.

See research article: webcite