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Open Access Research article

A functional genomics screen for microRNA regulators of NF-kappaB signaling

Anthony O Olarerin-George13, Lauren Anton2, Yih-Chii Hwang1, Michal A Elovitz2 and John B Hogenesch13*

Author Affiliations

1 Genomics and Computational Biology Graduate Group, 1420 Blockley Hall, 423 Guardian Drive, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

2 Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, 1354 Biomedical Research Building II/III, 421 Curie Blvd., Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

3 Department of Pharmacology and the Institute for Translational Medicine and Therapeutics, Smilow Translational Research Center 10-124, 3400 Civic Center Blvd., Bldg. 421, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

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BMC Biology 2013, 11:19  doi:10.1186/1741-7007-11-19

Published: 28 February 2013

Additional files

Additional file 1:

Supplemental tables. Table S1. miRNA library annotation; Table S2. Primary screen data; Table S3. Number of predicted targets per miRNA hit; Table S4. Comparison of genome-wide miRNA screens for regulators of NF-κB.

Format: XLSX Size: 107KB Download file

Open Data

Additional file 2:

Supplemental figures. Figure S1. p65 siRNA validation; Figure S2. Functional analysis of miR-517a/c in primary HUVECs; Figure S3. TNIP1 overexpression in HEK293 cells; Figure S4. TNF time course treatment in HEK293 cells; Figure S5. miR-517a/c-induced apoptosis in HUVECs.

Format: PDF Size: 576KB Download file

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Open Data