Resolution:
standard / ## Figure 3.
Exploration of model parameters based on treatments with chromatin-modifying agents. (A) Evolution of mean fluorescence intensity following kinetics of treatment with trichostatin
A (TSA; solid line) and 5-azacytidine (5-AzaC; dotted line) (0 to 48 hours) for three
cellular clones. (B) Distributions of the plausible chromatin dynamics. For each clone, all 114 possible
couples of (1/k; 1/_{on}k) values were plotted, expressed as mean open time (1/_{off}k) and mean closed time (1/_{off}k), after removal of all parameter sets that were not able to account for the transcription-translation
dynamics under TSA and 5-AzaC treatments. _{on}(C) This experiment was the same as for (B), except than the transcription rate (ρ) and the mean open time (1/k) parameters were reduced to a single effective parameter (_{off}ρ/k), representing the mean burst size. min, minutes; h, hours; d, days; m, months.
_{off}Viñuelas |