Additional file 1: Figure S1.
Muscle dysfunction is due to polyQ expression. (a,b) Swimming motions (bends per minute) were scored in (a) day 1 or (b) day 2 adult Q40Bristol and Q40DR1350 animals grown on control (empty vector) or yellow fluorescent protein (YFP) RNA interference (RNAi). YFP RNAi decreases expression of Q40-YFP fusion protein, resulting in improvement in motility. YFP RNAi was partially effective in a DR1350 background. (a) Q40Bristol animals had little loss of motility on control plates at day 1, but had (b) a significant loss of motility on day 2. (c) Motility of the non-transgenic parental strains, at least 15 animals per genotype. (a, b) Independent experiments, 15 and 10 animals per treatment, respectively. (a, c) Data were analyzed by ANOVA followed by Bonferroni’s multiple comparison test, α = 0.01, **P>0.001 and <0.01, ***P<0.001. (b) Data were analyzed by unpaired t-test, two-tailed, P<0.0001.
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Gidalevitz et al. BMC Biology 2013 11:100 doi:10.1186/1741-7007-11-100