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HIV takes double hit before entry

Rogier W Sanders

Author affiliations

Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065, USA

Citation and License

BMC Biology 2012, 10:99  doi:10.1186/1741-7007-10-99

Published: 7 December 2012


In the absence of a vaccine or a cure, identification of novel HIV-1 inhibitors remains important. A paper in Retrovirology describes a rationally designed bi-specific protein that irreversibly damages the viral envelope glycoprotein complex via a two-punch mechanism. In contrast to traditional drugs that inhibit essential steps in the viral life cycle at the cell surface or in the infected cells, this inhibitor cripples free virus in the absence of cells.

See research article: webcite