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Open Access Commentary

Tackling thermosensation with multidimensional phenotyping

William R Schafer

Author Affiliations

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK

BMC Biology 2012, 10:91  doi:10.1186/1741-7007-10-91

See research article:

Published: 19 November 2012


Most if not all animals sense temperature using specialized thermosensory neurons. Genetic studies in simple organisms have been used to identify gene products required for detecting temperature changes or for mediating the effects of temperature on behaviour. A recent study has used automated imaging and multidimensional phenotyping to characterize behavioural responses to aversive temperature changes and to identify mutants with specific defects in these processes.