Resolution:
## Figure 1.
Bimodal distribution in an output signal y due to cell-to-cell variability in an input
signal x. (a) The input-output response curve is piecewise linear with a smooth junction at the
activation threshold (between × = 30 and 40; black dots correspond to the case of
the 'black' line in (b)). (b) The input signal × was assumed to satisfy the Gamma distribution. (c) Bimodal and even trimodal distributions in the output signal y appear as the cell-to-cell
variability in × increases while its mean value is fixed. The distributions or histograms
were obtained after transforming × to log(x). (d) Some of the bimodal distributions in (c) still appear in a linear scale. (e-h) A smaller mean value of × was used. Bimodal distributions, observed at the log-scale,
were highly suppressed or disappeared in a linear scale. The sample size for the distributions
was 10^{5}.
Kim and Sauro |