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Open Access Highly Accessed Commentary

Chromatin roadblocks to reprogramming 50 years on

Peter J Skene and Steven Henikoff*

Author Affiliations

Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA

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BMC Biology 2012, 10:83  doi:10.1186/1741-7007-10-83

Published: 29 October 2012

Abstract

A half century after John Gurdon demonstrated nuclear reprogramming, for which he was awarded the 2012 Nobel Prize in Physiology or Medicine, his group provides insights into the molecular mechanisms whereby chromatin remodeling is required for nuclear reprogramming. Among the issues addressed in Gurdon's latest work are the chromatin impediments to artificially induced reprogramming, discovered by Shinya Yamanaka, who shared the award with Gurdon.

See research article: http://www.epigeneticsandchromatin.com/content/5/1/17 webcite