Figure 1.

Differential susceptibility of hippocampal subregions to NMDA-induced excitotoxicity is correlated with microglial morphology. CA1 neurons (red) are most vulnerable to excitotoxicity, compared with CA3 and dentate gyrus (DG) neurons (blue). In response to NMDA challenge, microglia within CA1 adopt an activated morphology, whilst microglia within protected regions retain a ramified appearance (insets).