Shedding light on local kinase activation
1 Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine,1959 Pacific Ave. NE, Seattle, WA 98195 USA
2 Department of Pharmacology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
BMC Biology 2012, 10:61 doi:10.1186/1741-7007-10-61Published: 17 July 2012
Phosphorylation is the predominant language of cell signaling. And, as with any common language, an abundance of dialects has evolved to convey complex information. We discuss here how biosensors are being used to decode this language, affording an unprecedented glimpse into spatio-temporal patterns of protein phosphorylation events within the cell.