Table 1

General features of the transcriptional response to genome mistranslations

GO term

Genes in term

T40' genes

P-value

T60' genes

P-value

T90' genes

P-value

T120' genes

P-value

T180' genes

P-value


protein targeting to mitochondrion

53

18

3·10-10


regulation of protein metabolic process

276

48

2·10-12

35

3·10-10

51

2·10-25


transposition

135

32

3·10-22

40

2·10-25

28

2·10-20


macromolecule biosynthetic process

1675

106

4·10-10

106

3·10-9

133

8·10-32


vacuolar protein catabolic process

118

15

5·10-7

15

4·10-5

15

2·10-8

14

3·10-5


response to heat

198

21

5·10-3

16

8·10-5

19

2·10-4

19

3·10-8

17

3·10-4


response to toxin

31

5

1·10-3

5

5·10-4

8

5·10-6


translation

731

124

3·10-32

102

2·10-35

32

5·10-5

131

4·10-75


regulation of translation

190

47

2·10-18

11

3·10-3

50

1·10-32


regulation of translational fidelity

15

5

2·10-4

3

3·10-3

7

2·10-7


maturation of SSU-rRNA

94

20

3·10-10

8

7·10-4

26

1·10-17


ribosome assembly

69

13

1·10-4

16

4·10-9

24

5·10-19


ribosome biogenesis

360

33

6·10-3

43

1·10-11

16

4·10-3

60

1·10-27


For each of the time-point DEGs, a hypergeometric test was applied over each GO biological process (R package GOstats), selecting GO terms with P-value lower than 10-3. The GO terms considered for mistranslations are either enriched for four or more time points, or have a significance level below a P-value of 10-9 for a single time point. This method provides about 40 GO terms that, after manually removing redundant and generic terms, result into the terms displayed in Table 1.

Paredes et al. BMC Biology 2012 10:55   doi:10.1186/1741-7007-10-55

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