Figure 7.

UBXN7 docks on neddylated cullins using its UIM motif. Each domain in UBXN7 mediates a specific interaction: the UBA domain interacts with ubiquitylated HIF1α, the UIM motif anchors the neddylated CRL complex and the UBX domain recruits the p97/NPL4/UFD1 complex.

Bandau et al. BMC Biology 2012 10:36   doi:10.1186/1741-7007-10-36
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