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Open Access Highly Accessed Commentary

Salamanders and fish can regenerate lost structures - why can't we?

Hans-Georg Simon

Author affiliations

Department of Pediatrics, Northwestern University, The Feinberg School of Medicine, Children's Memorial Research Center, 2300 Children's Plaza, Chicago, IL 60614, USA

Citation and License

BMC Biology 2012, 10:15  doi:10.1186/1741-7007-10-15

Published: 27 February 2012

Abstract

The recent introduction of in vivo lineage-tracing techniques using fluorescently labeled cells challenged the long-standing view that complete dedifferentiation is a major force driving vertebrate tissue regeneration. The report in BMC Developmental Biology by Juan Carlos Izpis├║a Belmonte and colleagues adds a new twist to a rapidly evolving view of the origin of blastemal cells. As classic and recent experimental findings are considered together, a new perspective on vertebrate muscle regeneration is emerging.

See research article http://www.biomedcentral.com/1471-213X/12/9 webcite