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Open Access Highly Accessed Commentary

Salamanders and fish can regenerate lost structures - why can't we?

Hans-Georg Simon

Author Affiliations

Department of Pediatrics, Northwestern University, The Feinberg School of Medicine, Children's Memorial Research Center, 2300 Children's Plaza, Chicago, IL 60614, USA

BMC Biology 2012, 10:15  doi:10.1186/1741-7007-10-15

Published: 27 February 2012


The recent introduction of in vivo lineage-tracing techniques using fluorescently labeled cells challenged the long-standing view that complete dedifferentiation is a major force driving vertebrate tissue regeneration. The report in BMC Developmental Biology by Juan Carlos Izpis├║a Belmonte and colleagues adds a new twist to a rapidly evolving view of the origin of blastemal cells. As classic and recent experimental findings are considered together, a new perspective on vertebrate muscle regeneration is emerging.

See research article webcite