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The design of the SAFE or SORRY? study: a cluster randomised trial on the development and testing of an evidence based inpatient safety program for the prevention of adverse events

Betsie GI van Gaal1*, Lisette Schoonhoven1, Marlies EJL Hulscher1, Joke AJ Mintjes2, George F Borm3, Raymond TCM Koopmans4 and Theo van Achterberg1

Author affiliations

1 IQ healthcare, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands

2 Faculty of Health and Social Studies, HAN University of Applied Sciences, Nijmegen, the Netherlands

3 Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands

4 Department of Primary and Community Care, Centre for family Medicine, Geriatric Care and Public Health Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands

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Citation and License

BMC Health Services Research 2009, 9:58  doi:10.1186/1472-6963-9-58


The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1472-6963/9/58


Received:16 February 2009
Accepted:1 April 2009
Published:1 April 2009

© 2009 van Gaal et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background

Patients in hospitals and nursing homes are at risk of the development of, often preventable, adverse events (AEs), which threaten patient safety. Guidelines for prevention of many types of AEs are available, however, compliance with these guidelines appears to be lacking. Besides general barriers that inhibit implementation, this non-compliance is associated with the large number of guidelines competing for attention. As implementation of a guideline is time-consuming, it is difficult for organisations to implement all available guidelines. Another problem is lack of feedback about performance using quality indicators of guideline based care and lack of a recognisable, unambiguous system for implementation. A program that allows organisations to implement multiple guidelines simultaneously may facilitate guideline use and thus improve patient safety.

The aim of this study is to develop and test such an integral patient safety program that addresses several AEs simultaneously in hospitals and nursing homes. This paper reports the design of this study.

Methods and design

The patient safety program addresses three AEs: pressure ulcers, falls and urinary tract infections. It consists of bundles and outcome and process indicators based on the existing evidence based guidelines. In addition it includes a multifaceted tailored implementation strategy: education, patient involvement, and a computerized registration and feedback system. The patient safety program was tested in a cluster randomised trial on ten hospital wards and ten nursing home wards. The baseline period was three months followed by the implementation of the patient safety program for fourteen months. Subsequently the follow-up period was nine months. Primary outcome measure was the incidence of AEs on every ward. Secondary outcome measures were the utilization of preventive interventions and the knowledge of nurses regarding the three topics. Randomisation took place on ward level. The results will be analysed separately for hospitals and nursing homes.

Discussion

Major challenges were the development of the patient safety program including a digital registration and feedback system and the implementation of the patient safety program.

Trial registration

Trial registration: ClinicalTrials.gov ID [NCT00365430]

Background

Over the past seventeen years several studies showed that patients are at risk of injuries or even death as a result of care delivered in hospitals [1-11]. These studies show that 2.9 to 16.6% of patients in acute care hospitals experienced at least one adverse event (AE) (Table 1) [1,2,9-11]. In 5 to 13% of these events the patients died [1-3,7,9-11]. Half of all events are considered preventable [1,3,6,9-11]. While these studies did not include nursing homes, other studies show that AEs, such as urinary tract infection, pneumonia, falls, pressure ulcers and medication errors, also occur frequently in nursing homes [12-14]. These events can often be linked directly to suboptimal nursing care, and they are generally considered preventable.

Table 1. Definitions

Many guidelines for the improvement of nursing care are available, however compliance with these guidelines appears to be lacking [15]. Generally, many factors or barriers may influence compliance -or noncompliance- with a guideline. These general barriers may be related to the individual (e.g. knowledge, skills, attitudes, motivation) or the individual's social context (e.g. patients, colleagues, culture), and the organisational setting (e.g. financial, equipment). Moreover, the large number of guidelines competing for attention makes it difficult to keep track of all of them. In addition organisations must translate each guideline to their own target group, and develop and organise their own information and education, which is a time-consuming process. Also, there is a lack of insight into actual performance of guideline based care, e.g. by using quality indicators [16]. As a result it is difficult to implement all available guidelines necessary for good quality daily nursing care. This situation is at odds with the responsibility of professionals to ensure patient safety. A program that allows organisations to implement multiple guidelines simultaneously may facilitate guideline use and thus improve patient safety.

The aim of this study is to develop and test such an integral patient safety program that addresses several AEs simultaneously in hospitals and nursing homes.

In this paper we will report on the design of this study, which has two phases. The first phase concerns the development of the patient safety program for three frequently occurring nursing care related AEs: pressure ulcers, falls and urinary tract infections. The second phase describes the evaluation of the patient safety program in a cluster randomised trial.

Methods and design

Phase 1: the development of the patient safety program

General focus of the program

From September 2005 – July 2006 we developed the integral patient safety program (SAFE or SORRY?) for the prevention of pressure ulcers, falls and urinary tract infections in hospitals and nursing homes. The program consists of bundles [17] (Table 1) and outcome and process indicators based on evidence based guidelines for pressure ulcers, falls and urinary tract infections.

For the implementation of guidelines, multifaceted implementation strategies are probably more effective than single strategies, as multifaceted strategies address multiple barriers to guideline adherence [16]. Therefore, we aimed at developing a multifaceted strategy for the implementation of these bundles.

Development

We developed the patient safety program with experts on each topic by collecting the existing guidelines [18-26] and supplementary material [27-40]. Based on this information the research group and the experts achieved consensus about the essence of the guidelines and formulated the bundles and indicators (Table 2). They developed a multifaceted implementation strategy consisting of education, patient involvement, feedback through a computerized registration program and an implementation plan for every ward (Table 3).

Table 2. Process (P) and outcome (O) indicators

Table 3. Operational implementation strategies

Tailoring

We discussed the bundles and indicators with the user group. This group consisted of two researchers (LS and BGIvG), seventeen future users of the patient safety program, two medical doctors and an implementation expert (MEJLH) and met five times. During the first meeting everyone was informed about the aim and work methods. During the next three meetings the group was split up into two smaller groups: a group with users from the hospitals and a group with users from the nursing homes. In each group we had focus discussions about the use of the bundles and indicators and the expected barriers for implementation. During the fifth meeting the group tested the computerized registration program. With this information, and the outcome on the knowledge test from the baseline measurement (phase 2), we tailored the education for the nurses to each individual ward in the intervention group. In a last meeting, the users of the intervention group tested the final educational material and the patient information. In order not to contaminate the control group with the elaborated education material and patient information, the users of this group were not invited to this last meeting.

Table 3 describes the concrete implementation strategies for the patient safety program. In addition, every intervention ward appointed two key nurses to the study. Together with the head nurse they were responsible for the implementation of the patient safety program on their ward. At the start of the implementation period these key nurses received a training in the use of the patient safety program. We also discussed the results of the baseline measurements (phase 2) and the educational material, and all educational activities on the wards were planned and organised. The key nurses and the researcher had periodical contact about the progress on the ward, throughout the implementation period.

Phase 2: cluster randomised clinical trial to evaluate the patient safety program

Study design and setting

A cluster randomised trial was conducted between September 2006 and November 2008 in the Netherlands. Hospitals and nursing homes were asked to participate with two or four, more or less comparable, wards. The hospital wards (n = 10) were internal medicine wards (n = 4) and surgical wards (n = 6) from four hospitals. The nursing home wards (n = 10) were wards with patients with physical impairments (no dementia)(n = 7) or rehabilitation wards (n = 3) from six nursing homes. The randomisation of the wards was stratified for centre and type of ward (Figure 1) and took place prior to baseline data collection.

thumbnailFigure 1. Randomisation.

Baseline data collection took place from September through November 2006. Subsequently, the patient safety program was implemented on the intervention wards: five hospital wards and five nursing home wards from December 2006 – February 2008. The wards of the control group continued care as usual. The follow-up period was nine months and continued until the end of November 2008.

The Medical Ethics Committee of district Arnhem – Nijmegen assessed the study and waived the need for complete evaluation of the study.

Study population

Adult patients (≥ 18 years) admitted to the hospitals or the nursing homes during our study, were asked to participate. Hospital patients with an expected stay of at least five days were asked within 48 hours after admission. After a written informed consent the research assistants visited the patients once a week. All patients with at least a second visit were included in this study.

All (clinical) nurses at the wards participated in our study. Nurses' aids and students were excluded.

Outcome measures

The primary outcome measure was the incidence of AEs (sum of the incidence of pressure ulcers, urinary tract infections and falls).

A pressure ulcer is an area of localised damage to the skin and underlying tissue caused by a combination of pressure and shear[21]. Pressure ulcers are classified in four grades according to the guidelines [19,21,40]. Pressure ulcers were considered present if a patient developed a PU grade 2 or worse. If a patient had a PU grade two or worse at the first visit, that PU lesion was excluded from the registration of PUs until the PU healed. Patients with an already present PU grade two or worse were only registered if they developed additional PU lesions.

A urinary tract infection is bacteriuria with clinical symptoms as: frequent urinating, pain while urinating, abdominal pain, fever and delirium, urinary incontinence [18,24]. During this study we defined a urinary tract infection as present if it was diagnosed by a medical doctor. Patients were excluded from the registration of urinary tract infection for a period of three weeks if they had a urinary tract infection until the infection was cured.

A fall is an unexpected event in which the participant comes to rest on the ground, floor, or lower level [20,41]. In this study the falls were measured by examining the patient files, assuming that if a patient fell it was reported in his or her file.

The secondary outcome measures were 1) the percentage of patients that received preventive care and 2) the knowledge of nurses regarding the three topics.

Prevention is important in patients at risk for one of the AEs. Preventive measurements were considered present when the care was performed according to the guideline.

The risk of pressure ulcers was measured with the PrePURSE [27] and the Braden scale [42] in hospitals and nursing homes, respectively. Next preventive care was measured: position while lying or sitting; if patients' heels were lifted; use of pressure-reducing material or alternating pressure material in bed or chair; presence of a repositioning scheme.

Hospital patients were at risk for a urinary tract infection if they had at least one of the next four risk factors [18,23]: 1) a urinary catheter in situ or the week before, 2) incontinence of faeces, 3) urinary retention or 4) a urinary tract infection in the last two years. According to the guideline, all nursing home patients were considered at risk for a urinary tract infection [18]. Next preventive care was measured: personal hygiene, frequent toilet visits, unnecessary indwelling catheter and unobstructed urine flow.

To identify hospital patients at risk for falls we used the STRATIFY [43]. According to the guideline all nursing home patients were considered at risk for falls, except those who were totally immobile [20]. Next preventive care was measured: if the file had a written multidisciplinary plan with multi-factorial preventive interventions; a periodic evaluation of the multidisciplinary plan; a periodic evaluation of the multi-factorial risk factors for falls.

The knowledge of nurses about risk assessment and effective preventive care was measured using a written knowledge test. Each topic had twenty questions, on which nurses could answer 'correct', 'not correct', or 'do not know'.

The knowledge test was developed from questionnaires [44] (knowledge test used in an implementation study of a pressure ulcer guideline in the Netherlands (Schoonhoven, L. 2004) and geriatric educational material of the prevention of falls, 2007) and student tests of the HAN University of Applied Sciences on the three topics. The face validity was tested by sending the questionnaire to the members of the research group (LS, JAJM, RTCMK and TvA), and the expert on each topic. Finally, nurses in hospitals and nursing homes were asked to pretest the questionnaire.

Data collection

During the baseline and follow up period, the patient data were collected in two ways. To measure AEs and preventive care the research assistants read the patient files and observed the patients during a weekly visit. To measure the utilization of preventive care, wards were visited three times by research assistants. At each visit they observed a sample of at least five patients and nurses during their daily activities for five hours.

All nurses were asked to fill in a questionnaire at the start of the baseline period and the follow-up period.

Statistics

Power calculation was based on the primary outcome, with a two-sided alpha of 0.05 and 80% power for the analysis of both the hospital and the nursing homes data.

As randomisation was on ward level, a ward was considered to be a cluster. To account for these clusters an intra class correlation coefficient of 0.01 was used in the calculation.

In hospitals, the incidence of pressure ulcers (10%) will be the highest contributor to our combined AE measure. The incidence of urinary tract infection and falls in the same patients is unknown. Therefore we assumed that the count of these three AEs will be 12% (an additional 1% for falls and 1% for urinary tract infections). We aimed to achieve a reduction of 50% as studies on the prevention of pressure ulcers have shown this is attainable [45,46]. To detect a decrease in AEs (from 12% – 6%) 1250 patients had to be included in each hospital group.

In the nursing homes, the incidence of falls will be the highest (60%). We assume that the additional contribution of pressure ulcers and urinary tract infection to AEs will be negligible. We aimed to achieve a reduction of 60% as a study on the prevention of falls showed this was attainable [47]. Therefore this study wanted to achieve a reduction of AEs from 60 – 36%. To detect this decrease in the nursing homes, 100 patients had to be included in each group.

The results will be analysed separately for hospitals and nursing homes, as patient characteristics, length of stay and nurse characteristics differ between hospitals and nursing homes.

The difference in incidence of AEs between the intervention and the control group during the follow up period will be analysed using a random effects Poisson regression analysis, including the following covariates: ward (random effect), institution and the baseline results of the ward.

The secondary outcomes will be evaluated in a similar way, using linear and logistic random effect models.

Discussion

As implementation of a guideline is time-consuming, it is difficult for organisations to implement all available guidelines. Also, lack of feedback about performance using quality indicators of guideline based care and lack of a recognisable, unambiguous system for implementation often impede guideline implementation. A program that allows organisations to implement multiple guidelines simultaneously may facilitate guideline use and thus improve patient safety.

This study posed several challenges concerning the development of the complex intervention, the implementation of this intervention and the design of the trial. For the development of our intervention we used available guidelines on each topic. Translating three extensive guidelines into a manageable proposal for improving patient care is not easy. We chose to combine the essence of each guideline into a recognizable simple structural approach, and reduced the guidelines on each topic into two or three bundles. These bundles were easier to use in daily practice. The aim of the digital registration and feedback system was to provide the nurses on the ward with feedback on the performance of guideline based care. As we anticipated that nurses have limited computer skills and limited time to register all patients daily, we paid extra attention to the accessibility and performance of the digital program. This program was subsequently pre-tested during the first phase of this study in a group of future users and it was obvious that we had managed to develop a digital registration and feedback system that was user-friendly for all nurses on the wards. Also, the time it takes to register all patients on the wards was considered acceptable.

Our next challenge was the implementation of our intervention. Many factors may enhance or inhibit implementation. Therefore it is important to analyse the target group [16]. To be successful, we developed a multifaceted implementation strategy that could be tailored to each specific ward. By tailoring the strategy to the barriers of the individual wards we developed an individual implementation plan for each ward that considered the context of that particular ward.

The implementation of the digital registration and feedback system was even more complex. Currently, registration of patient care in a computer is not a standard procedure in the Netherlands. The nursing files are still mainly paper files. Moreover, not all nurses of the participating wards were used to working with a computer and on some wards the nurses did not even have access to a computer or the internet. We explored these barriers in a very early stage of the implementation process. This allowed us to remove the practical barriers, i.e. attaining access to a computer and the internet, and organise training programs for nurses to improve computer skills. Also, it gave the wards the opportunity to adopt the idea of registration of patient care on a computer. By the time they had to work with the digital registration and feedback system they were already used to the idea of using a computer.

Unfortunately it was not possible to prevent double registration of patient data: nurses had to write patient files and also register the patient daily care in the computer. This is only worthwhile when the digital program is of benefit to the nurses. Therefore, nurses were trained and encouraged to use the feedback provided by the digital program to evaluate and adjust daily care.

The final challenge we want to discuss is the design of the cluster randomised trial. Cluster randomised trials are more complex to perform, as they require more participants [48], due to the correlation between individuals in the same ward. In this study we took this into account by including an intra cluster correlation coefficient in the power calculation. As a result we had to include many hospital patients: 1250 in each group. To include and follow up that many patients in such a short time is ambitious, but we are convinced that it is achievable. Also, analyses of cluster randomised trials are complex. For analysing the effect of an intervention, a regression analysis including covariates should be used to account for the influence of the wards. Therefore this study will consider the following covariates: ward (random effect), institution and the baseline results of the ward.

Dissemination of the results of this study is planned for 2009.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

BGIvG wrote the article, developed the patient safety program, coordinated the study, prepared instruments for the study, and collected and analysed data. LS wrote the article, has been involved in the development of the patient safety program, preparing the instruments for the study, is the supervisor of the study. MEJLH had an important input during the development of the implementation strategies and tailoring of het implementation plan and in revising the article. JAJM has been involved in the development of the patient safety program and in revising the article. GFB is the statistician and has been involved in the design of the study. He performed the power calculation and the sample size considerations. RTCMK has been involved in the development of the patient safety program and in revising the article. TvA has been involved in the development of the patient safety program, preparing the instruments for the study, is the general supervisor of the study and in revising the article.

All authors approved the final version of the manuscript.

References

  1. Baker GR, Norton PG, Flintoft V, Blais R, Brown A, Cox J, et al.: The Canadian Adverse Events Study: the incidence of adverse events among hospital patients in Canada.

    CMAJ 2004, 170:1678-1686. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  2. Brennan TA, Leape LL, Laird NM, Hebert L, Localio AR, Lawthers AG, et al.: Incidence of adverse events and negligence in hospitalized patients: results of the Harvard Medical Practice Study I. 1991.

    Qual Saf Health Care 2004, 13:145-151. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  3. Davis P, Lay-Yee R, Briant R, Ali W, Scott A, Schug S: Adverse events in New Zealand public hospitals I: occurrence and impact.

    N Z Med J 2002, 115:U271. PubMed Abstract OpenURL

  4. Hayward RA, Hofer TP: Estimating hospital deaths due to medical errors: preventability is in the eye of the reviewer.

    JAMA 2001, 286:415-420. PubMed Abstract | Publisher Full Text OpenURL

  5. Jarman B, Gault S, Alves B, Hider A, Dolan S, Cook A, et al.: Explaining differences in English hospital death rates using routinely collected data.

    BMJ 1999, 318:1515-1520. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  6. Michel P, Quenon JL, de Sarasqueta AM, Scemama O: Comparison of three methods for estimating rates of adverse events and rates of preventable adverse events in acute care hospitals.

    BMJ 2004, 328:199. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  7. Park RE, Brook RH, Kosecoff J, Keesey J, Rubenstein L, Keeler E, et al.: Explaining variations in hospital death rates. Randomness, severity of illness, quality of care.

    JAMA 1990, 264:484-490. PubMed Abstract | Publisher Full Text OpenURL

  8. Schioler T, Lipczak H, Pedersen BL, Mogensen TS, Bech KB, Stockmarr A, et al.: [Incidence of adverse events in hospitals. A retrospective study of medical records].

    Ugeskr Laeger 2001, 163:5370-5378. PubMed Abstract OpenURL

  9. Thomas EJ, Studdert DM, Burstin HR, Orav EJ, Zeena T, Williams EJ, et al.: Incidence and types of adverse events and negligent care in Utah and Colorado.

    Med Care 2000, 38:261-271. PubMed Abstract | Publisher Full Text OpenURL

  10. Vincent C, Neale G, Woloshynowych M: Adverse events in British hospitals: preliminary retrospective record review.

    BMJ 2001, 322:517-519. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  11. Wilson RM, Runciman WB, Gibberd RW, Harrison BT, Newby L, Hamilton JD: The Quality in Australian Health Care Study.

    Med J Aust 1995, 163:458-471. PubMed Abstract OpenURL

  12. Pierson S, Hansen R, Greene S, Williams C, Akers R, Jonsson M, et al.: Preventing medication errors in long-term care: results and evaluation of a large scale web-based error reporting system.

    Qual Saf Health Care 2007, 16:297-302. PubMed Abstract | Publisher Full Text OpenURL

  13. Gruneir A, Mor V: Nursing home safety: current issues and barriers to improvement.

    Annu Rev Public Health 2008, 29:369-382. PubMed Abstract | Publisher Full Text OpenURL

  14. Koopmans RT, Hoogen HJ, van Weel C: Incidentie en prevalentie van gezondheidsproblemen bij een groep dementerende verpleeghuispatienten. Een vergelijking met de huisartspraktijk. [Incidence and prevalence of health problems in a group of nursing home patients with dementia. A comparison with family practice].

    Tijdschr Gerontol Geriatr 1994, 25:231-236. PubMed Abstract OpenURL

  15. Halfens R, Van Linge R: Disseminatie en implementatie van kennis [Dissemination and implementation of knowledge]. Utrecht: Elsevier/LEVV; 2003. OpenURL

  16. Grol R, Wensing M, Eccles M: Improving Patient Care: The implementation of Change in Clinical Practice. London: Elsevier; 2005. OpenURL

  17. Everdingen JJE, Smorenburg SM, Schellekens W, Cucic S: Patient Safety Toolbox: Instruments for improving safety in health care organisations. Houten: Bohn Stafleu van Loghum; 2007. OpenURL

  18. Beroepsvereniging van verpleeghuisartsen en sociaal geriaters (NVVA): Richtlijn Urineweginfecties [Guideline Urinary Tract Infections]. Utrecht: Beroepsvereniging van verpleeghuisartsen en geriaters (NVVA); 2006. OpenURL

  19. Centraal Begeleidings Orgaan: [http://www.cbo.nl/product/richtlijnen/folder20021023121843/decubitus2002.pdf?] webcite

    Richtlijn Decubitus [Second revision pressure ulcers]. Utrecht. 2002. OpenURL

  20. Centraal Begeleidings Orgaan: Preventie van valincidenten bij ouderen [Guidelines Fall Prevention in the Elderly]. Alphen aan den Rijn: Van Zuiden Communications; 2004. OpenURL

  21. Defloor T, Herremans A, Grypdonck MH, De Schuijmer JD, Paquay L, Schoonhoven L, et al.: Belgische richtlijn decubituspreventie 2005 [Belgium guideline Prevention of Pressure Ulcers]. Gent: Academia Press; 2005. OpenURL

  22. Nederlandse Vereniging van Verpleeghuisartsen:

    Tripartiete multidisciplinaire richtlijn: Samenwerking en logistiek rond decubitus [Tripartite multidisciplinary guideline: Collaboration and logistic proces of Pressure Ulcers. Utrecht. 2003. OpenURL

  23. Werkgroep Infectiepreventie: Preventie van infecties als gevolg van blaaskatheterisatie via de urethra [Prevention of Catheter-associated urinary tract infections]. Leiden: Leids Universitair Medisch Centrum; 2005. OpenURL

  24. Werkgroep Infectiepreventie: Definities ziekenhuisinfecties [Definitions hospital infections]. Leiden: Leids Universitair Medisch Centrum; 2005. OpenURL

  25. Werkgroep Infectiepreventie: Handhygiëne medewerkers ziekenhuizen [Hand hygiene Health care workers in Hospitals]. Leiden: Leids Universitair Medisch Centrum; 2003. OpenURL

  26. Werkgroep Infectiepreventie: Handhygiëne Verpleeghuis- woon- en thuiszorg [Hand hygiene Nursing homes and Long-term care facilities]. Leiden: Leids Universitair Medisch Centrum; 2004. OpenURL

  27. Schoonhoven L, Grobbee DE, Donders AR, Algra A, Grypdonck MH, Bousema MT, et al.: Prediction of pressure ulcer development in hospitalized patients: a tool for risk assessment.

    Qual Saf Health Care 2006, 15:65-70. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  28. Vanderwee K, Grypdonck MH, Defloor T: Effectiveness of an alternating pressure air mattress for the prevention of pressure ulcers.

    Age Ageing 2005, 34:261-267. PubMed Abstract | Publisher Full Text OpenURL

  29. Defloor T: Wisselhouding, minder frequent en toch minder decubitus [Less frequent turning intervals and yet less pressure ulcers].

    Tijdschr Gerontol Geriatr 2001, 32:174-177. PubMed Abstract OpenURL

  30. Defloor T, Schoonhoven L, Fletcher J, Furtado K, Heyman H, Lubbers M, et al.: Statement of the European Pressure Ulcer Advisory Panel-Pressure Ulcer Classification: Differentiation Between Pressure Ulcers and Moisture Lesions.

    J Wound Ostomy Continence Nurs 2005, 32:302-306. PubMed Abstract | Publisher Full Text OpenURL

  31. Milisen K, Staelens N, Schwendimann R, De PL, Verhaeghe J, Braes T, et al.: Fall Prediction in Inpatients by Bedside Nurses Using the St. Thomas's Risk Assessment Tool in Falling Elderly Inpatients (STRATIFY) Instrument: A Multicenter Study.

    J Am Geriatr Soc 2007, 55:725-733. PubMed Abstract | Publisher Full Text OpenURL

  32. Gillespie L: Preventing falls in elderly people.

    BMJ 2004, 328:653-654. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  33. Gillespie LD, Gillespie WJ, Robertson MC, Lamb SE, Cumming RG, Rowe BH: Interventions for preventing falls in elderly people.

    Cochrane Database Syst Rev 2003, CD000340. PubMed Abstract | Publisher Full Text OpenURL

  34. Neyens JC, Dijcks BP, de KA, Graafmans WC, Schols JM: CBO guidelines to prevent accidental falls in the elderly: how can it be used in the institutionalized elderly?

    Tijdschr Gerontol Geriatr 2005, 36:155-160. PubMed Abstract OpenURL

  35. Vloet LC: Postprandial and orthostatic hypotension in the elderly: Implications for nursing care. PhD thesis. University Medical Centre Nijmegen; 2003. OpenURL

  36. Nicolle LE: Urinary tract infections in long-term-care facilities.

    Infect Control Hosp Epidemiol 2001, 22:167-175. PubMed Abstract | Publisher Full Text OpenURL

  37. Nicolle LE: Catheter-related urinary tract infection.

    Drugs Aging 2005, 22:627-639. PubMed Abstract | Publisher Full Text OpenURL

  38. Nicolle LE: The chronic indwelling catheter and urinary infection in long-term-care facility residents.

    Infect Control Hosp Epidemiol 2001, 22:316-321. PubMed Abstract | Publisher Full Text OpenURL

  39. Defloor T, Clark M, Witherow A, Colin D, Lindholm C, Schoonhoven L, et al.: EPUAP statement on prevalence and incidence monitoring of pressure ulcer occurrence 2005.

    J Tissue Viability 2005, 15:20-27. PubMed Abstract OpenURL

  40. European Pressure Ulcer Advisory Panel (EPUAP): Guidelines on treatment of pressure ulcers.

    EPUAP Review 1999, 1:31-33. OpenURL

  41. Hauer K, Lamb SE, Jorstad EC, Todd C, Becker C: Systematic review of definitions and methods of measuring falls in randomised controlled fall prevention trials.

    Age Ageing 2006, 35:5-10. PubMed Abstract | Publisher Full Text OpenURL

  42. Braden BJ, Bergstrom N: Predictive validity of the Braden Scale for pressure sore risk in a nursing home population.

    Res Nurs Health 1994, 17:459-470. PubMed Abstract | Publisher Full Text OpenURL

  43. Oliver D, Britton M, Seed P, Martin FC, Hopper AH: Development and evaluation of evidence based risk assessment tool (STRATIFY) to predict which elderly inpatients will fall: case-control and cohort studies.

    BMJ 1997, 315:1049-1053. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  44. Van Achterberg T, Eliens AM, Strijbol NCM: Effectief Verplegen 1: Handboek ter onderbouwing van het verpleegkundig handelen [Effective Nursing 1: Handbook evidence for nursing care]. 2nd edition. Dwingeloo: Kavanah; 2002. OpenURL

  45. Defloor T: Drukreductie en Wisselhouding in de preventie van decubitus [Pressure reduction and repositioning in the prevention of pressure ulcers]. PhD thesis. Universisty of Gent Belgium: Medical Social Sciences, University of Gent, Belgium; 2000. OpenURL

  46. Centraal Begeleidings Orgaan: [http:/ / www.cbo.nl/ info_cbo/ folder20090212162916/ folder20030902144742/ article20030902145238/ articleCBOextra_view] webcite

    Continue verbetering van decubituszorg: door sturen steeds beter (Afgerond Doorbraak Project) [Continuously improving preventive care for Pressure Ulcers (finished project)]. 2003. OpenURL

  47. Jensen J, Nyberg L, Gustafson Y, Lundin-OIsson L: Fall and Injury Prevention in Residential Care – Effects in Residents with Higher and Lower Levels of Cognition.

    Annals of Internal Medicine 2002, 136:733-741. PubMed Abstract | Publisher Full Text OpenURL

  48. Campbell MK, Elbourne DR, Altman DG: CONSORT statement: extension to cluster randomised trials.

    BMJ 2004, 328:702-708. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

Pre-publication history

The pre-publication history for this paper can be accessed here:

http://www.biomedcentral.com/1472-6963/9/58/prepub