|
Example of a modified GRADE evidence profile summary of findings. Table 9 and 10 is what Table 1 and 2 became when including the improvements made based on the pilot study experience |
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| Outcome |
SSRI |
Tricyclics |
Effect |
Quality |
Importance |
|
|
|
||||||
| Relative (95% CI) |
Absolute |
|||||
|
|
||||||
| Depression severity |
5044 patients |
4510 patients |
WMD 0.034 (-0.007 to 0.075) |
No difference |
Moderate |
Critical |
| Transient side effects |
1948/7032 (28%) |
2072/6334 (33%) |
RRR 13% (5% to 20%) |
5 per 100 |
High |
Critical |
| Poisoning fatalities*** |
1/100,000 per year of treatment |
58/100,000 per year of treatment |
RRR 98% (97% to 99%) |
6 per 10,000 |
Moderate |
Critical |
|
***There is uncertainty about the baseline risk for poisoning fatalities. | ||||||
Atkins et al. BMC Health Services Research 2005 5:25 doi:10.1186/1472-6963-5-25 |
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