Open Access Research article

Evaluating adverse drug event reporting in administrative data from emergency departments: a validation study

Corinne M Hohl123*, Lisa Kuramoto3, Eugenia Yu4, Basia Rogula3, Jürgen Stausberg5 and Boris Sobolev36

Author Affiliations

1 Department of Emergency Medicine, University of British Columbia, 855 West 12th Avenue, Vancouver, BC V5Z 1 M9, Canada

2 Department of Emergency Medicine, Vancouver General Hospital, 855 West 12th Avenue, Vancouver, BC V5Z 1 M9, Canada

3 Centre for Clinical Epidemiology & Evaluation, Vancouver Coastal Health Research Institute, 828 West 10th, Vancouver, BC V5Z 1 M9, Canada

4 Department of Statistics, University of British Columbia, 900 West 10th Ave, Vancouver, BC V5Z 1 M9, Canada

5 InstitutfürMedizinischeInformationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-UniversitätMünchen, München, Germany

6 School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada

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BMC Health Services Research 2013, 13:473  doi:10.1186/1472-6963-13-473

Published: 12 November 2013

Additional files

Additional file 1:

ADE Evaluation Algorithm at the Point-of-Care. In the ED each patient was evaluated by a clinical pharmacist and the treating emergency physician independently, and blinded to each other’s evaluations. The ratings were combined while the patient was still in the ED. If there was any disagreement about the rating (i.e., yes/no, yes/uncertain, no/uncertain, etc.), or if either or both of the evaluations were uncertain, the case proceeded to independent adjudication by a committee consisting of a pharmacist and physician not in any other way involved in the study.

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Additional file 2:

Adverse drug events were diagnosed only in patients presenting to the emergency department with untoward and unintended symptoms, signs or abnormal laboratory values that arose from appropriate or inappropriate medication use. Events meeting this case definition were categorized according to the taxonomy of drug-related problems [25]. For all events that were categorized as due to “Need to Add Drug/Untreated Indication” or “Failure to Receive a Drug/Noncompliance” a pre-existing diagnosis had to have been documented prior to the emergency department visit. Failure to use a drug in the first place was not considered an adverse drug event. Asymptomatic drug-related problems were not captured. Adverse drug reactions were defined according to the World Health Organization [31].

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Additional file 3:

See code set provided in an Excel spreadsheet.

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