Table 5

Risk of congenital anomalies among the offspring of RNs according to weighted duration of exposure to antineoplastic drugs (method 2), 1986-2000 (N = 22,491)1,2

Congenital anomaly category

(ICD9 code)

Weighted duration of

exposure3

Exposure during first trimester of

pregnancy

Exposure during 10 years preceding

pregnancy

cases

OR4

CI (95%)

cases

OR4

CI (95%)


All congenital anomalies

< 15 days

1,328

1.00

1229

1.00

(740-759)

≥ 15 days

63

0.93

0.72-1.21

162

0.98

0.82-1.16

Nervous system

< 15 days

51

1.00

47

1.00

(740-742)

≥ 15 days

< 3

6

0.96

0.41-2.24

Eye

< 15 days

89

1.00

81

1.00

(743)

≥ 15 days

6

1.31

0.57-3.00

14

1.26

0.71-2.22

Ear, face, neck

< 15 days

85

1.00

82

1.00

(744)

≥ 15 days

4

0.96

0.35-2.64

7

0.64

0.30-1.39

Heart

< 15 days

137

1.00

127

1.00

(745-746)

≥ 15 days

10

1.44

0.75-2.74

20

1.15

0.72-1.84

Other circulatory system

< 15 days

127

1.00

115

1.00

(747)

≥ 15 days

8

1.26

0.61-2.58

20

1.28

0.79-2.06

Cleft palate/lip

< 15 days

29

1.00

25

1.00

(749)

≥ 15 days

< 3

6

1.84

0.75-4.49

Upper alimentary tract

< 15 days

83

1.00

81

1.00

(750)

≥ 15 days

4

0.93

0.34-2.55

6

0.55

0.24-1.25

Other digestive system

< 15 days

35

1.00

32

(751)

≥ 15 days

< 3

5

1.17

0.46-3.01

Genital organs

< 15 days

213

1.00

192

1.00

(752)

≥ 15 days

6

0.55

0.24-1.25

27

1.06

0.70-1.59

Urinary system

< 15 days

101

1.00

93

1.00

(753)

≥ 15 days

5

0.97

0.39-2.38

13

1.05

0.59-1.88

Musculoskeletal system

< 15 days

443

1.00

419

1.00

(754-756)

≥ 15 days

18

0.80

0.49-1.28

42

0.74

0.54-1.02

Integument

< 15 days

96

1.00

88

1.00

(228, 757)

≥ 15 days

5

1.01

0.41-2.49

13

1.08

0.60-1.94

Chromosomal anomalies

< 15 days

60

1.00

56

1.00

(758)

≥ 15 days

< 3

4

0.54

0.20-1.49

Multiple anomalies

< 15 days

15

1.00

13

1.00

(759.7-759.8)

≥ 15 days

< 3

3

1.76

0.50-6.19


1 Congenital anomalies with an incidence of less than 3 cases were excluded.

2 N for ≥ 15 days of antineoplastic drug exposure during first trimester of pregnancy = 1,062; during 10 years preceding pregnancy = 2,650.

3 A weighted duration of exposure of 15 days is equivalent to full-time work for one year (240 days) at a job considered unlikely to be exposed; a weighted duration of exposure of 60 days is equivalent to full-time work for one year at a job considered possibly exposed.

4 Adjusted for sex, year of birth, and age of mother.

Ratner et al. BMC Nursing 2010 9:15   doi:10.1186/1472-6955-9-15

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