Table 1

Supporting evidence for combination drug simulation result.

Drug A

Drug B

Drug development State


Metformin

Saxagliptin

FDA approved

Metformin

Sitagliptin

FDA approved

Metformin

Vildagliptin

FDA approved

Metformin

Miglitol

Literature [26]

Metformin

Voglibose

FDA approved

Metformin

Liraglutide

Phase 3

Metformin

Mitiglinide

Phase 3

Metformin

Nateglinide

Literature [27]

Metformin

Repaglinide

FDA approved

Metformin

Glipizide

FDA approved

Metformin

Gliquidone

Literature [28]

Metformin

Glimepiride

FDA approved

Metformin

Glyburide

FDA approved

Metformin

Pioglitazone

FDA approved

Metformin

Rosiglitazone

FDA approved


We simulated twenty-one pairs of combination drug that consisted with metformin. It was identified that the sixteen among twenty-one pairs of combination drug have efficacy. Fifteen pairs of combination drug have strong evidence of efficacy from previous clinical studies: ten pairs are FDA-approved and two pairs are in clinical trials. And also three pairs have been investigated in several literatures [26-28].

Hwang et al. BMC Medical Informatics and Decision Making 2013 13(Suppl 1):S4   doi:10.1186/1472-6947-13-S1-S4

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