Figure 3.

Variation of total phenytoin, adjusted phenytoin, and free phenytoin with respect to plasma albumin concentration. (A) Variation of the difference between PHTtotal/10 and PHTfree with respect to plasma albumin concentration. All data is from chronologically first phenytoin measurements in 756 patients. The dashed line is from linear regression: [PHTtotal/10 - PHTfree] = -2.136 + 0.477 * [albumin concentration] (R2 = 0.19). The 95% confidence intervals of the intercept is (-2.37, -1.90) and for the slope is (0.406, 0.549). (B) Variation of the difference between PHTfree and PHTadj_free with respect to plasma albumin concentration using same source of patient data in (A). The dashed line is from linear regression: [PHTfree - PHTadj_free] = 0.0838 + 0.0021*[plasma albumin] (R2 = 0.004). The 95% confidence intervals of the intercept is (-0.138, 0.305) and for the slope is (-0.0649, 0.0691)

Krasowski and Penrod BMC Medical Informatics and Decision Making 2012 12:7   doi:10.1186/1472-6947-12-7
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