## Figure 3.
Variation of total phenytoin, adjusted phenytoin, and free phenytoin with respect
to plasma albumin concentration. (A) Variation of the difference between PHT_{total/10 }and PHT_{free }with respect to plasma albumin concentration. All data is from chronologically first
phenytoin measurements in 756 patients. The dashed line is from linear regression:
[PHT_{total/10 }- PHT_{free}] = -2.136 + 0.477 * [albumin concentration] (R^{2 }= 0.19). The 95% confidence intervals of the intercept is (-2.37, -1.90) and for the
slope is (0.406, 0.549). (B) Variation of the difference between PHT_{free }and PHT_{adj_free }with respect to plasma albumin concentration using same source of patient data in
(A). The dashed line is from linear regression: [PHT_{free }- PHT_{adj_free}] = 0.0838 + 0.0021*[plasma albumin] (R^{2 }= 0.004). The 95% confidence intervals of the intercept is (-0.138, 0.305) and for
the slope is (-0.0649, 0.0691)
Krasowski and Penrod |