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Open Access Research article

Clinical decision support of therapeutic drug monitoring of phenytoin: measured versus adjusted phenytoin plasma concentrations

Matthew D Krasowski1* and Louis E Penrod23

Author Affiliations

1 Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA

2 Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA

3 Baptist Health South Florida, Miami, FL 33176, USA

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BMC Medical Informatics and Decision Making 2012, 12:7  doi:10.1186/1472-6947-12-7

Published: 14 February 2012

Additional files

Additional file 1:

Figure S1 (correlation of PHTfree versus PHTtotal/10 and PHTfree versus PHTadj_free), Figure S2 (Bland-Altman plots), Figure S3 (three-by-three contingency tables of PHTtotal and PHTfree), Figure S4 (three-bv-three contingency tables of PHTadj_free and PHTfree comparing those with recent seizures or no recent seizures), Figure S5 (three-bv-three contingency tables of PHTadj_free and PHTfree comparing those on phenytoin monotherapy versus polytherapy with other anti-epileptic drugs), Figure S6 (effect of albumin concentration on free phenytoin estimation), and Figure S7 (effect of patient age on free phenytoin estimation).

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