Table 2

Spot check of NSCLC genes/proteins for their relevance to biomarker applicability and evidence
Gene or protein No. of retrieved document Relative entropy rank Frequency based rank Example PMID Biomarker applicability Biomarker evidence
P53 281 1 1 20521348 Prognosis Expression
VEGFA 128 6 4 21964530 Prognosis Expression
BCL2 90 8 6 19560836 Survival Expression
PCNA 47 11 10 21495034 Prognosis Expression
VEGFC 22 16 21 19758816 Recurrence Expression
PTGS2 33 25 15 20592629 Survival Expression
CDKN1B 12 50 52 15483027 Prognosis Expression
DNAJB4 2 100 344 16788156 Survival Expression
CDK2 5 342 112 10817513 Prognosis No impact

For the SCAIView search the MeSH disease “Carcinoma, Non-Small-Cell Lung” in combination with five biomarker retrieval classes (omitting the class Antecedent) were selected and the retrieved genes were ranked according the Relative Entropy or frequency. In spot tests the abstracts were analysed for containing biomarker information for the respective genes.

Younesi et al.

Younesi et al. BMC Medical Informatics and Decision Making 2012 12:148   doi:10.1186/1472-6947-12-148

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