Table 2

Views of Local IRBs Regarding CIRB Review

    Perceived Problems and Ambivalence Concerning Local IRBs


▪ Problems concerning local IRBs often recognized


▪ But general wariness of CIRBs, and support for local IRBs



    Perceived Advantages of Local IRBs


▪ Claims that local IRBs reflect community values


▪ Local knowledge of subjects


◦ Of vulnerable populations


◦ Therefore, easier to judge risks and benefits


▪ Local knowledge of PIs


◦ "Track records"/reputations


▪ Protecting "our own" subjects


◦ Perceived responsibilities to protect local patients


▪ "Curbside consults" with PIs


◦ Formal and informal


◦ Can facilitate mutual trust


◦ More dialogue


◦ Appreciation of local institutional culture


▪ Desires for local autonomy, authority, and comfort


◦ Against "being told what to do"


◦ Wariness of centralized, federal bureaucracy



    Perceived Problems with CIRBs


▪ Differences between CIRBs


◦ Depends on who are members of the committee


▪ For-profit CIRBs may have conflicts of interest



    Advantages of CIRBs


▪ Rarely acknowledged


▪ Streamlining work


◦ Saving Time



    Disadvantages of Local IRBs


▪ Discrepancies can arise due to:


◦ Institutional culture and history


◦ Personalities



    Local Members as Biased in Their Views of CIRBs?



    Other Possible Solutions


▪ More guidance


▪ More regional IRBs?


Klitzman BMC Medical Ethics 2011 12:13   doi:10.1186/1472-6939-12-13

Open Data