Table 1

Test characteristics of personal genome testing and their implications for the discourse on ELSI

Test characteristic

Implications

ELSI


From targeted to non-targeted testing

Quantity and complexity of information

The information problem

- Informed consent

- Information provision (pre-test and post-test)

- Informational updates

- Incidental findings


Analytical validity

High analytical validity

Regulatory issues


Clinical validity

Generally poor clinical validity (validity varies per disease tested for)

- Psychological risks, health risks and societal risks

- Regulatory issues


Clinical utility

Generally poor clinical utility (utility varies per disease tested for)

- Personal perspectives on utility

- Changing interpretations (fluidity of information)


Bunnik et al. BMC Medical Ethics 2011 12:11   doi:10.1186/1472-6939-12-11

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