Table 6

Pharmacodynamic geometric mean ratios of AVI-014/filgrastim at 8 μg/kg

Hematologic

Parameter

Dose μg/kg

Geometric Mean AVI-014 (n = 8)

Geometric Mean Filgrastin (n = 8)

P value

Geometric Mean Ratio (90% CI)


WBC

AUC(0–9)

8

1444.7

1574.1

0.3824

0.92 (0.78, 1.09)


Cmax

8

415.9

435.7

0.6617

0.95 (0.79, 1.15)


ANC

AUC(0–9)

8

1974.4

2268.9

0.4626

0.87 (0.63, 1.21)


Cmax

8

661.3

739.6

0.6230

0.89 (0.60, 1.34)


CD 34+

AUC(0–6)

8

3121.6

2791.2

0.8785

1.12 (0.31, 3.99)


Cmax

8

1373.2

1315.9

0.9569

1.04 (0.26, 4.11)


Varki et al. BMC Clinical Pharmacology 2009 9:2   doi:10.1186/1472-6904-9-2

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