Table 5

Pharmacodynamic geometric mean ratios of AVI-014/filgrastim at 4 μg/kg

Hematologic

Parameter

Dose μg/kg

Geometric Mean AVI-014 (n = 8)

Geometric Mean Filgrastin (n = 8)

P value

Geometric Mean Ratio (90% CI)


WBC

AUC(0–9)

4

1343.9

1193.6

0.1473

1.13 (0.98, 1.29)


Cmax

4

375.1

326.7

0.1737

1.15 (0.97, 1.36)


ANC

AUC(0–9)

4

2146.3

1560.3

0.0489

1.38 (1.06, 1.78)


Cmax

4

735.9

515.8

0.0690

1.43 (1.04, 1.96)


CD 34+

AUC(0–6)

4

3208.8

3088.9

0.9613

1.04 (0.27, 4.06)


Cmax

4

1322.7

1186.3

0.8875

1.12 (0.29, 4.24)


Varki et al. BMC Clinical Pharmacology 2009 9:2   doi:10.1186/1472-6904-9-2

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