Table 7

Comparison of average urine excretion of essential and other minerals compared to baseline.

Baseline

st dev

Change after 1st dose

Change after 9th dose

RDA for 4-8 yr (mg)

% of RDA lost #


Cu

0.022

0.008

74%***

129%***

0.44

3%

K

2187

1491

110%***

48%**

1500

57%

Fe

0.016

0.055

93%+

64%

10

0.1%

Mn

0.0023

0.0016

77%***

37%*

1.5

<0.1%

Zi

0.00034

0.00069

90%

13%

n/a

Li

0.10

0.10

51%

50%

n/a

V

0.025

0.013

49%***

10%

Cr

0.091

0.044

47%***

11%

0.015

88%

Zn

0.81

0.49

8%

30%***

5

2%

Na

3901

2018

35%***

3%

n/a

B

2.5

2.0

25%*

11%

n/a

Ba

0.0050

0.0052

12%

22%

n/a

S

1140

694

3%

9%

n/a

Mg

168

64

-5%

17%*

130

4%

Se

0.20

0.16

3%

0%

30

6%

Co

0.0014

0.0013

-4%

4%

n/a

Ca

137

115

-6%

3%

800

no extra loss

St

0.25

0.15

-5%

0%

n/a

P

1160

627

-5%

-4%

500

No extraloss

Mo

0.13

0.13

-5%

-33%*

0.022

No extra loss


+ P < 0.1

*P < 0.05

** P < 0.01

*** P < 0.001

# Averaged over 3 days, assuming production of creatinine is 500 mcg/day, which is typical for a 60-pound child

N = 63. Units are mg/g-creatinine (note difference from table 2 and 3, which are mcg/g-creatinine). Arranged in approximate order of increase in urinary excretion. The extra loss of minerals due to increased urinary excretion is also listed in terms of the RDA. Results for potassium (K) and chromium (Cr) are highlighted due to the large % of RDA.

Adams et al. BMC Clinical Pharmacology 2009 9:16   doi:10.1186/1472-6904-9-16

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