Platelet count. a: Platelet Count before DMSA. Note many children have values above the reference range (130-450 k/mm3). One child had a very high value (1996 k/mm3) which is not shown on this chart. b: Platelet Count 1-2 months after first round of DMSA. The primary effect of DMSA is to decrease the elevated platelets, with little effect on those in the normal or low range. One child still had a very high value (1917 k/mm3) which is not shown on this chart. c: Platelet Count at End of Study. Both the 7-round and 1-round groups are plotted together, as the results were similar, although there was slightly more decrease for the 7-round than the 1-round group. The primary effect of DMSA is to normalize elevated or (in one case) low platelets. One child still has a high value of 1195 k/mm3 which is not shown, but it has decreased substantially from its initial value of 1996 k/mm3).
Adams et al. BMC Clinical Pharmacology 2009 9:16 doi:10.1186/1472-6904-9-16