RBC glucathione distributions. a: Initial RBC Glutathione Distribution (pre-treatment). Many autistic children have levels below and above the laboratory's reference range of 427-714 micromolar. Each histogram corresponds to the frequency between that value and 50 below it; ie, the histogram labelled "50" is the frequency of values from 0 to 50. b: RBC Glutathione Distribution 1-2 months after first round (3 days) of DMSA. The distribution has tightened dramatically, so that most children are within the laboratory's reference range for typical adults. c: Change in RBC glutathione 1-2 months after first round of DMSA. Children with initially low levels had a large increase in glutathione, and children with high levels had a large decrease, so that most levels of glutathione normalized. The black dots are the participants who received DMSA and glutathione lotion and the red dots are the participants who received DMSA and the placebo lotion. The trendlines for the two groups lie directly on top of one another, suggesting that the effect of the glutathione lotion is negligible compared to the effect of the DMSA.
Adams et al. BMC Clinical Pharmacology 2009 9:16 doi:10.1186/1472-6904-9-16