Table 3

Pharmacokinetic profile

Study medication
Water Volume
Dose pre-meal
AUC0–4 pg/ml × hrs
Cmax pg/ml
Tmax minutes

SMC021
50 ml
10 min
52.2 (46.0–59.4)
103 (89–118)
15 (10–23)
SMC021
50 ml
30 min
68.9 (60.2–78.9)
125 (110–144)
15 (15–30)
SMC021
50 ml
60 min
74.4 (64.0–86.5)
145 (125–168)
15 (15–30)

SMC021
200 ml
10 min
27.4 (25.2–29.7)
52 (45–59)
15 (10–15)
SMC021
200 ml
30 min
32.9 (29.1–37.3)
56 (48–67)
15 (15–30)
SMC021
200 ml
60 min
33.6 (29.5–38.1)
49 (42–58)
15 (12.5–30)

Miacalcic
N/A
60 min
16.4 (13.8–19.4)
11.4 (8.3–15.5)
15 (10–15)

AUC0–4 and Cmax is given as geometric mean (mean ± 1 sem), and Tmax as median (25–75 percentile)

Karsdal et al. BMC Clinical Pharmacology 2008 8:5   doi:10.1186/1472-6904-8-5