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Peak Changes in Physiological Variables in Response to Inhaled l-Methamphetamine, IV phenylephrine and IV l-methamphetamine. |
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| Measure |
16 Inhalations |
32 Inhalations |
64 Inhalations |
PE1 |
PE2 |
IV l-Meth |
Overall P-Value |
|
|
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| Systolic Blood Pressure (mmHg) |
11.8 (16.2)‡§||** |
12.3 (20.5)‡§||** |
- 1.2 (16.0) |
0.9 (10.1) |
1.4 (9.8) |
2.9 (9.3) |
0.03 |
| Diastolic Blood Pressure (mmHg) |
8.7 (8.9)||** |
6.6 (9.9)|| |
9.0 (12.4)||** |
1.9 (8.3) |
-2 (10.2) |
7.4 (12.5)|| |
0.04 |
| Heart Rate (beats/min) |
1.3 (12.3) |
4.2 (19.2) |
2.3 (14.3) |
2.8 (9.7) |
-4.2 (7.9) |
- 0.33 (8.4) |
0.62 |
| Respiratory Rate (breaths/min) |
0.17 (4.3) |
3 (2.5)*§||** |
2.4 (3.5)§|| |
- 1.9 (4.8) |
-1.5 (3.3) |
0.42 (4.4) |
0.003 |
| Core Temperature (°C) |
0.13 (0.8) |
- 0.32 (0.9) |
0.21 (0.9) |
- 0.19(0.6) |
0.08 (0.4) |
0.09 (0.2) |
0.41 |
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Data presented as mean (SD). PE1 = phenylephrine dose 1; PE2 = phenylephrine dose 2; IV l -Meth = IV l-methamphetamine * = significantly greater than 16 inhalations † = significantly greater than 32 inhalations ‡ = significantly greater than 64 inhalations § = significantly greater than PE1 || = significantly greater than PE2 ¶ significantly greater than IV l-methamphetamine ** = significantly greater than baseline | |||||||
Mendelson et al. BMC Clinical Pharmacology 2008 8:4 doi:10.1186/1472-6904-8-4 |
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