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PK parameters of nicotine in plasma after swallowing without sucking of increasing numbers of 1 mg lozenge (mean ± SD; n = 8 per group) |
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| Group\PK parameter |
A |
B |
C |
|
|
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| 3 lozenges |
6 lozenges |
12 lozenges |
|
|
|
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| Cmax (ng/ml) |
8.2 ± 7.6 |
16.9 ± 11.8 |
20.5 ± 8.8 |
| tmax (h) |
2.7 ± 2.8 |
2.8 ± 2.0 |
2.2 ± 1.4 |
| AUC10 min-12 h (h.ng/ml) |
37.0 ± 27.2 |
84.9 ± 48.9 |
103.1 ± 58.6 |
|
PK parameters were not corrected for baseline plasma nicotine levels. | |||
Dautzenberg et al. BMC Clinical Pharmacology 2007 7:11 doi:10.1186/1472-6904-7-11 |
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