Table 4 |
||||||
|
Intestinal absorption parameters for oral ramipril: 1) the major ramipril absorption component (gamma function, A, a, and T); 2) a slow, long ramipril component (Aslow); and 3) direct intestinal conversion and absorption of ramiprilat (gamma function, AR, a and T). The total oral dose is 2.5 mg (6010 nanomoles). The total amount absorbed = A + Aslow+ AR. |
||||||
|
Subject |
Ramipril- Major component |
Slow absorp. Amount Aslow (nmole) |
Ramprilat Amount AR (nmole) |
Total Absorption (nmole) |
||
|
|
||||||
|
Amount (A) (nmole) |
Time const. (T) (min) |
Gamma (a) |
||||
|
|
||||||
|
1 |
2500 |
90 |
3 |
787 |
200 |
3487 |
|
3 |
1200 |
53 |
9 |
367 |
60 |
1627 |
|
4 |
1600 |
45 |
8 |
432 |
30 |
2062 |
|
5 |
1400 |
48 |
3.2 |
0 |
100 |
1500 |
|
6 |
1800 |
35 |
3 |
0 |
100 |
1900 |
|
7 |
800 |
25 |
3 |
320 |
41 |
1161 |
|
8 |
2100 |
70 |
2 |
756 |
200 |
3056 |
|
9 |
2200 |
65 |
6 |
0 |
100 |
2300 |
|
10 |
1800 |
60 |
5.5 |
0 |
100 |
1900 |
|
11 |
1100 |
35 |
3 |
346 |
100 |
1546 |
|
12 |
2700 |
80 |
4 |
0 |
400 |
3100 |
|
|
||||||
|
Ave (SD) |
1745 (597) |
55.1 (20.1) |
4.4 (2.3) |
273 (301) |
130 (105) |
2149 (755) |
|
|
||||||
|
Levitt and Schoemaker BMC Clinical Pharmacology 2006 6:1 doi:10.1186/1472-6904-6-1 |
||||||
