Research article
Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat
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* Corresponding author: David G Levitt levit001@umn.edu
1 Department of Physiology, University of Minnesota, 6-125 Jackson Hall, 321 Church St. S. E., Minneapolis, MN 55455, USA
2 Centre for Human Drug Research Zernikedreef 10, 2333CL Leiden, The Netherlands
BMC Clinical Pharmacology 2006, 6:1 doi:10.1186/1472-6904-6-1
Published: 6 January 2006Additional files
Additional File 1:
Section I: Detailed derivation of mathematical description of slow tight binding solutes. Section II: Derivation of relationship between 60 minute ACE assay and true in vivo ACE activity. Section III: Analysis of the sensitivity of the model predictions to parameter variations for IV ramiprilat. Section IV: Analysis of the sensitivity of the model predictions to parameter variations for IV and oral ramipril.
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