Table 2

Individual and mean pharmacokinetic parameters of daidzein following a single dose of orally administered soy beverage (B) and soy extract capsules (C).
Subj No.
 Cmax (ng/ml)
 Cmax/Dose1
 AUC0–32 (ng.h/ml)
 AUC0–32/Dose1
 AUC0-∝ (ng.h/ml)
 AUC0-∝/Dose1
 Tmax (h)
 t1/2 (h)


B
 C
 B
 C
 B
 C
 B
 C
 B
 C
 B
 C
 B
 C
 B
 C
1
 67.42
 60.73
 7.27
 7.80
 354.62
 650.40
 38.25
 83.49
 496.21
 722.51
 53.53
 92.75
 6
 6
 6.06
 8.04
2
 142.17
 56.33
 15.34
 7.23
 1142.38
 931.84
 123.23
 119.62
 1206.09
 1024.24
 130.11
 131.48
 6
 1
 6.74
 6.02
3
 64.95
 76.70
 7.01
 9.85
 1118.40
 1117.20
 120.65
 143.41
 1704.60
 1171.78
 183.88
 150.42
 8
 6
 19.80
 6.85
4
 132.30
 124.43
 14.27
 15.97
 1336.29
 1356.49
 144.15
 174.13
 1402.26
 1427.11
 151.27
 183.20
 6
 6
 6.70
 6.91
5
 77.66
 93.20
 8.38
 11.96
 1293.52
 1251.35
 139.54
 160.64
 1483.69
 1561.72
 160.05
 200.48
 8
 10
 9.94
 10.50
6
 105.65
 142.82
 11.40
 18.33
 1409.24
 1378.43
 152.02
 176.95
 1533.26
 1450.55
 165.40
 186.21
 10
 6
 6.21
 6.86
7
 160.86
 125.37
 17.35
 16.09
 1576.65
 1669.28
 170.08
 214.28
 1761.36
 1721.18
 190.01
 220.95
 4
 6
 8.48
 5.97
8
 102.77
 74.08
 11.09
 9.51
 1158.07
 1090.36
 124.93
 139.97
 1227.07
 1149.04
 132.37
 147.50
 6
 6
 6.85
 6.76
9
 45.34
 105.77
 4.89
 13.58
 300.89
 849.39
 32.46
 109.04
 340.35
 876.40
 36.72
 112.50
 4
 6
 3.46
 4.40
10
 52.98
 84.74
 5.72
 10.88
 401.82
 579.95
 43.35
 74.45
 533.03
 761.42
 57.50
 97.74
 1
 6
 4.82
 4.38
11
 99.98
 87.38
 10.79
 11.22
 1291.80
 1546.66
 139.35
 198.54
 1455.80
 1705.46
 157.04
 218.93
 8
 10
 6.59
 7.63
12
 103.60
 120.64
 11.18
 15.49
 578.60
 909.87
 62.42
 116.80
 665.06
 971.69
 71.74
 124.74
 4
 6
 6.49
 5.71
Mean
 96.31
 96.02ND
 10.39
 12.33
 996.86
 1110.94ND
 107.54
 142.61*
 1150.73
 1211.93ND
 124.14
 155.57*
 5.92
 6.25
 7.68
 6.67
SD
 36.18
 27.71
 3.90
 3.56
 455.69
 342.26
 49.16
 43.94
 504.94
 354.46
 54.47
 45.50
 2.43
 2.26
 4.14
 1.65

1Pharmacokinetic parameters adjusted for oral administered dose. ND = statistical analysis was not performed due to differences in oral administered doses between both preparations, *Statistical significance (p < 0.05) compared to corresponding values of soy extract capsules.

Anupongsanugool et al. BMC Clinical Pharmacology 2005 5:2   doi:10.1186/1472-6904-5-2