Table 2

Individual and mean pharmacokinetic parameters of daidzein following a single dose of orally administered soy beverage (B) and soy extract capsules (C).

Subj No.

Cmax (ng/ml)

Cmax/Dose1

AUC0–32 (ng.h/ml)

AUC0–32/Dose1

AUC0-∝ (ng.h/ml)

AUC0-∝/Dose1

Tmax (h)

t1/2 (h)


B

C

B

C

B

C

B

C

B

C

B

C

B

C

B

C


1

67.42

60.73

7.27

7.80

354.62

650.40

38.25

83.49

496.21

722.51

53.53

92.75

6

6

6.06

8.04

2

142.17

56.33

15.34

7.23

1142.38

931.84

123.23

119.62

1206.09

1024.24

130.11

131.48

6

1

6.74

6.02

3

64.95

76.70

7.01

9.85

1118.40

1117.20

120.65

143.41

1704.60

1171.78

183.88

150.42

8

6

19.80

6.85

4

132.30

124.43

14.27

15.97

1336.29

1356.49

144.15

174.13

1402.26

1427.11

151.27

183.20

6

6

6.70

6.91

5

77.66

93.20

8.38

11.96

1293.52

1251.35

139.54

160.64

1483.69

1561.72

160.05

200.48

8

10

9.94

10.50

6

105.65

142.82

11.40

18.33

1409.24

1378.43

152.02

176.95

1533.26

1450.55

165.40

186.21

10

6

6.21

6.86

7

160.86

125.37

17.35

16.09

1576.65

1669.28

170.08

214.28

1761.36

1721.18

190.01

220.95

4

6

8.48

5.97

8

102.77

74.08

11.09

9.51

1158.07

1090.36

124.93

139.97

1227.07

1149.04

132.37

147.50

6

6

6.85

6.76

9

45.34

105.77

4.89

13.58

300.89

849.39

32.46

109.04

340.35

876.40

36.72

112.50

4

6

3.46

4.40

10

52.98

84.74

5.72

10.88

401.82

579.95

43.35

74.45

533.03

761.42

57.50

97.74

1

6

4.82

4.38

11

99.98

87.38

10.79

11.22

1291.80

1546.66

139.35

198.54

1455.80

1705.46

157.04

218.93

8

10

6.59

7.63

12

103.60

120.64

11.18

15.49

578.60

909.87

62.42

116.80

665.06

971.69

71.74

124.74

4

6

6.49

5.71


Mean

96.31

96.02ND

10.39

12.33

996.86

1110.94ND

107.54

142.61*

1150.73

1211.93ND

124.14

155.57*

5.92

6.25

7.68

6.67


SD

36.18

27.71

3.90

3.56

455.69

342.26

49.16

43.94

504.94

354.46

54.47

45.50

2.43

2.26

4.14

1.65


1Pharmacokinetic parameters adjusted for oral administered dose. ND = statistical analysis was not performed due to differences in oral administered doses between both preparations, *Statistical significance (p < 0.05) compared to corresponding values of soy extract capsules.

Anupongsanugool et al. BMC Clinical Pharmacology 2005 5:2   doi:10.1186/1472-6904-5-2

Open Data