Comparison of D2O PBPK model arterial (black line) and antecubital vein concentrations with the experimental arterial (black squares) and antecubital (red squares) data of Schloerb et. al. . The red line shows the predicted model antecubital vein concentration using the "standard" arm parameters used in figs. 2, 3, 4, 5 (muscle arm flow fraction = 0.05). The blue line shows the model antecubital vein concentration with the fractional muscle arm blood flow contribution increased to 0.4.
Levitt BMC Clinical Pharmacology 2004 4:2 doi:10.1186/1472-6904-4-2